| Let’s begin with medicine from back in the day
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| When a priest and a medicine man were the same
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| I’m in pain, I’ve got a fever and I’m restless!
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| «A classic case of demon possession
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| I’ve got the cure though, here, take it easy
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| Drink this broth,
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| it’s made from endangered species
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| It works only when the weather’s not stormy
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| Now go sacrifice a goat and call me in the morning»
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| We practice medicine in similar ways today,
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| but now it’s nominally evidence-based
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| It used to be entirely mysterious but these
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| Days it’s just mysterious to various degrees
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| Thanks to Louis Pasteurization, vaccines
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| And discoveries like the germ theory of disease
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| But what about natural alternative medicine
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| Ayurvedic homeopathy and all the rest of it?
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| Well, if we can isolate and test it for effectiveness
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| Maybe some of it will be vindicated by evidence
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| And then it won’t be «alternative»,
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| it’ll be «medicine»
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| And whatever’s left?
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| Well, that we can jettison
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| Yeah, modern medicine is mechanistic
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| Treats the body like a machine,
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| attempts to fix it |
| But the picture’s incomplete without this next bit
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| Not just «how it works» but «why we get sick»
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| Why we get sick
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| We evolved to crave salt, sugar and fat
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| They were scarce in the past
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| So we get sick
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| Sit down,
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| take some weight off
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| Lower back pain results as a trade off
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| We get sick
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| The genes inside us are ancient,
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| surrounded by modern products
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| We get sick
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| Microbial arms races
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| Charles Darwin taught the basics
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| Of why we get sick
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| «Why does disease exist?»
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| Next time someone asks that,
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| don’t plead the fifth
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| I know your neighbour’s car has a Jesus fish
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| You wanna keep the peace,
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| and he believes a myth
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| But so what?
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| People die from untreated infections
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| And asking «why» implies natural selection
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| And that can lead to new research questions
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| So lives are lost to avoid bein' offensive?
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| Well that’s offensive
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| to life’s preservation
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| Every disease requires two explanations
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| The first one is proximate,
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| Doctor Gregory House
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| Tryin' to get the diagnosis and figure it out
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| What’s the broken mechanism?
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| Like a puzzle to solve |
| The second question is: How did this evolve?
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| Relax,
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| evolution is so simple
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| The DNA in your cells encodes info
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| For how to build a body to develop and thrive
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| Ultimately to reproduce and survive
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| So disease itself is not the adaptation
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| But you need adaptations to explain…
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| Why we get sick
|
| We evolved to crave salt, sugar and fat
|
| They were scarce in the past
|
| So we get sick
|
| Sit down, take some weight off
|
| Lower back pain results as a trade off
|
| We get sick
|
| The genes inside us are ancient,
|
| surrounded by modern products
|
| We get sick
|
| Microbial arms races
|
| Charles Darwin taught the basics
|
| Of why we get sick
|
| How does DNA make design?
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| With no intelligent mind?
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| It takes time
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| But any variation that increases reproduction
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| or random mutation that enhances some function
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| of feeding or developing or escaping from hitches
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| Will tend to increase in number — that’s fitness
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| Take infection, you can feel it, something’s wrong
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| But that’s an organism trying to get its reproduction on
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| Up in your guts,
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| no guts no glory
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| That’s just one of several evo-categories |
| Another is defenses,
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| you catch a fever
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| To cook the invader,
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| no bug, that’s a feature
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| Yeah, you have weapons to beat back infections
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| So don’t make rash decisions and mask symptoms
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| Dosing with iron when your blood is busy bindin' it
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| And watch out for mismatched environments
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| We evolved in the days of the cave man
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| Coca cola wasn’t really part of the game plan
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| And some diseases are all about genetics
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| You gotta take the gene’s eye view to really get it
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| Sometimes they go rogue,
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| it’s like starting a war
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| They send you to the oncology ward
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| Life is full of design compromises
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| Trade offs, you know,
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| kinda like with high rises
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| Strength for tensility,
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| speed for longevity
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| Live fast, die young,
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| breed prolifically
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| And yeah, humans are still evolving
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| But we’ve got a body plan,
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| so we can’t evolve wings
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| We had to wait to fly 'til someone thought of it
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| Cultural evolution, medicine is part of it
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| Cultural evolution, medicine is part of
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| Part of cultural evolution
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| Medicine is part of
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| Why we get sick
|
| We evolved to crave salt, sugar and fat |
| They were scarce in the past
|
| So we get sick
|
| Sit down, take some weight off
|
| Lower back pain results as a trade off
|
| We get sick
|
| The genes inside us are ancient,
|
| surrounded by modern products
|
| We get sick
|
| Microbial arms races
|
| Charles Darwin taught the basics
|
| Of why we get sick |